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4-Oxo-1,4-dihydroquinoline-3-carboxylic acid (CAS 13721-01-2)

4-Oxo-1,4-dihydroquinoline-3-carboxylic acid

Synonyms                    1,4-DIHYDRO-4-OXO-QUINOLINE-3-CARBOXYLIC ACID;
                                      4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID;
                                      1,2-Dihydro-4-oxo-quinoline-3-carboxylic acid;
                                      1,4-Dihydro-4-oxo-3-quinolinecarboxylic acid

Documents: COA  | MSDS

Packing  20'FCL Without /With pallets 40'FCL Without/With Pallets

1KG/Bag

25kg/Drums

N/A N/A
  • Specification
  • Feature&Application
  • Plant Details
  • FAQ
  • Properties
  • Standard

    Enterprise standard

    Appearance

    off-white  powder

    Assay

    ≥99.0%

    loss on drying

    ≤2.0%

    Residue on ignition

    ≤2.0%

  • Uses        4-Oxo-1,4-dihydroquinoline-3-carboxylic acid is intermediate of ivacaftor

     

                                                 Ivacaftor is used to treat cystic fibrosis in adults and children who are at least 6 months old and weigh at least 11 pounds (5 kilograms). Ivacaftor is for use only in patients with a specific gene mutation related to cystic fibrosis. Before you take ivacaftor, you may need a medical test to make sure you have this gene mutation.

  • 1.  what is its main application?

    It is  intermediate of  ivacaftor

    2.  how many years we produced it, and what is its capactity

    It produced since 2018。 And capacity is 20mt annually.

     

    3. what is plant location and nearest port

    It located in a chemical zone Fujian province., and nearest port is Xiamen port

    4.  if doc. Support and audit available?

    Yes, VQ and allied tech. package is available for serious client.  Audit could be accepted for clients having business more than 1 year.

    5.  what other products are producing or plan to produce in this plant 

    Advanced pharmaceutical intermediates,e.g. intermediats of Pramipexole,Rivastigmine,Ramatroban,ivacaftor,Olaparib etc.

  • Chemical Safety

     

    Irritant

     

    Property NameProperty ValueReference
    Molecular Weight 189.17 g/mol Computed by PubChem 2.1 (PubChem release 2019.06.18)
    XLogP3-AA 1.8 Computed by XLogP3 3.0 (PubChem release 2019.06.18)
    Hydrogen Bond Donor Count 2 Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18)
    Hydrogen Bond Acceptor Count 4 Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18)
    Rotatable Bond Count 1 Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18)
    Exact Mass 189.042593 g/mol Computed by PubChem 2.1 (PubChem release 2019.06.18)
    Monoisotopic Mass 189.042593 g/mol Computed by PubChem 2.1 (PubChem release 2019.06.18)
    Topological Polar Surface Area 66.4 Ų Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18)
    Heavy Atom Count 14 Computed by PubChem
    Formal Charge 0 Computed by PubChem
    Complexity 309 Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18)
    Isotope Atom Count 0 Computed by PubChem
    Defined Atom Stereocenter Count 0 Computed by PubChem
    Undefined Atom Stereocenter Count 0 Computed by PubChem
    Defined Bond Stereocenter Count 0 Computed by PubChem
    Undefined Bond Stereocenter Count 0 Computed by PubChem
    Covalently-Bonded Unit Count 1 Computed by PubChem
    Compound Is Canonicalized Yes Computed by PubChem (release 2019.01.04)

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